The two‐component regulatory system PhoP‐PhoQ of Pseudomonas aeruginosa regulates
resistance to cationic antimicrobial peptides, polymyxin B and aminoglycosides in response …

Resistance to the polycationic antibiotic polymyxin B and expression of the outer-membrane
protein OprH in the opportunistic pathogen Pseudomonas aeruginosa both involve the PhoP …

When grown in divalent cation-limited medium, Pseudomonas aeruginosa becomes
resistant to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by …

Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The
mutations responsible for this phenotype were mapped to a two-component signal …

As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …

Rapid adaptation to environmental challenge is essential for the survival of many bacterial
species, and is often effectively mediated by two‐component regulatory systems. Part of the …

Pseudomonas aeruginosa can develop resistance to polymyxin as a consequence of
mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification …

Pseudomonas aeruginosa, a gram-negative bacterium of human pathogens, is noted for its
environmental versatility, enormous metabolic capacity, and resistance to antibiotics …

Polymyxins are often the only option to treat acquired multidrug-resistant Pseudomonas
aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the …

Polymyxins B and E1 and gramicidin S are bacterium-derived cationic antimicrobial
peptides. The polymyxins were more potent than gramicidin S against Pseudomonas …