Phenotypic differences among closely related bacteria have been largely ascribed to
species-specific genes, such as those residing in pathogenicity islands. However, we now …

To assess the contribution of ppGpp in antibiotic tolerance to quinolone in Pseudomonas
aeruginosa, knockout mutants of the genes involved or linked with the stringent response …

Background The cationic peptide antibiotic polymyxin has recently been reevaluated in the
treatment of severe infections caused by gram negative bacteria. Methods In this study, the …

To test the possibility that MexX-MexY, a new set of efflux system components, is associated
with OprM and contributes to intrinsic resistance in Pseudomonas aeruginosa, we …

Antimicrobial peptides (APs) are important host weapons against infections. Nearly all APs
are cationic and their microbicidal action is initiated through interactions with the anionic …

Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug
efflux system produce reduced levels of several extracellular virulence factors known to be …

Despite limited data, polymyxin B (PB) is increasingly used clinically as the last therapeutic
option for multidrug-resistant (MDR) gram-negative bacterial infections. We examined the in …

Antimicrobial peptides (AMPs) form a crucial part of human innate host defense, especially
in neutrophil phagosomes and on epithelial surfaces. Bacteria have a variety of efficient …

ABSTRACT A mutant, named 11B, hypersusceptible to aminoglycosides, tetracycline, and
erythromycin was isolated after Tn 501 insertion mutagenesis of Pseudomonas aeruginosa …

ABSTRACT A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial
peptides (APs) than the wild type. Susceptibility did not result from surface changes other …