Evidence derived from several lines of investigation suggest that prostaglandins,
metabolites of arachidonic acid, play an important role in colon cancer development …

The revelation that aspirin and aspirin-like compounds have notableantineo plastic
properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

The rate-limiting step in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Colorectal cancer is an excellent model for studying cancer prevention by means of
secondary (eg, polypectomy to remove a precursor adenoma) and primary …

NSAIDs (non-steroidal anti-inflammatory drugs) prevent colon and other cancers. The fact
that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug-developmental work …

The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Inhibitors of the inducible cyclooxygenase (COX‐2) have emerged as a promising new class
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …

A considerable amount of evidence collected from several different experimental systems
indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large …

Background Various studies suggest that aspirin and other non-steroidal anti-inflammatory
drugs (NSAIDs) are promising anticancer agents. Epidemiological studies have found that …