Treatment of Philadelphia chromosome–positive acute lymphoblastic leukemia

OG Ottmann, B Wassmann - ASH Education Program Book, 2005 - ashpublications.org
Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) includes at
least one-quarter of all adults with ALL. Until recently, conventional chemotherapy programs …

Outcome of treatment in children with Philadelphia chromosome–positive acute lymphoblastic leukemia

M Aricò, MG Valsecchi, B Camitta… - … England Journal of …, 2000 - Mass Medical Soc
Background Children with Philadelphia chromosome–positive acute lymphoblastic leukemia
(Ph-positive ALL) have a poor prognosis, and there is no consensus on the optimal …

Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome‐positive adult acute lymphoblastic leukemia

PP Piccaluga, S Paolini, G Martinelli - Cancer, 2007 - Wiley Online Library
Acute lymphoblastic leukemia (ALL) is a heterogeneous disorder, with the greatest
prevalence in children, but it also affects adults, and has an increasing incidence with age …

Pediatric-inspired treatment regimens for adolescents and young adults with Philadelphia chromosome–negative acute lymphoblastic leukemia: a review

SE Siegel, W Stock, RH Johnson, A Advani… - JAMA …, 2018 - jamanetwork.com
Importance The incidence of acute lymphoblastic leukemia (ALL) and lymphoblastic
lymphoma (LBL) in adolescent and young adult (AYA) patients (age range, 15-39 years) in …

Genomics in acute lymphoblastic leukaemia: insights and treatment implications

KG Roberts, CG Mullighan - Nature reviews Clinical oncology, 2015 - nature.com
Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL

KG Roberts, YL Yang, D Payne-Turner, W Lin… - Blood …, 2017 - ashpublications.org
New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like
ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by …

Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology …

WM Crist, AJ Carroll, JJ Shuster, J Jackson, D Head… - 1990 - ashpublications.org
Among 3,638 children with acute lymphoblastic leukemia (ALL) entered on Pediatric
Oncology Group (POG) protocols between June 1981 and April 1989, successful …

Philadelphia-positive acute lymphoblastic leukemia: current treatment options

T Liu-Dumlao, H Kantarjian, DA Thomas… - Current oncology …, 2012 - Springer
Abstract The Philadelphia chromosome (Ph), t (9; 22), is seen in about 20% to 30% of adults
diagnosed with acute lymphoblastic leukemia (ALL). It has been associated with poorer …

Long‐term follow‐up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with P hiladelphia chromosome–positive acute …

F Ravandi, SM O'Brien, JE Cortes, DM Thomas… - Cancer, 2015 - Wiley Online Library
BACKGROUND The long‐term efficacy of a combination of chemotherapy and dasatinib in
patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) …

Outcome of treatment in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia—results of the prospective multicenter LALA-94 trial

H Dombret, J Gabert, JM Boiron… - Blood, The Journal …, 2002 - ashpublications.org
From 1994 to 2000, 154 adults with Philadelphia chromosome–positive (Ph+) and/or BCR-
ABL+ acute lymphoblastic leukemia (ALL) were treated according to a prospective trial …