It has been established that the permeability of the human placenta increases with
advancing gestation. Indirect evidence has also proposed that aquaporins (AQPs) may be …

Three water channel proteins, aquaporins, have been shown to be expressed in the
placentae of humans and sheep—AQP1, 3, 8; AQP1 is in the vasculature, whereas AQP3, 8 …

The syncytiotrophoblast of human term placenta (HST) is a continuous, multinucleated
structure with minimal tight junctions, which results from the fusion of the underlying …

OBJECTIVES: To assess the role of aquaporins (AQPs) in the regulation of amniotic fluid
(AF) volume, we determined AF volume and composition and placental and fetal membrane …

OBJECTIVE: Aquaporin 9 (AQP9) is one of the recently identified water channels that is also
permeable to neutral solutes including urea. To investigate the molecular mechanism of …

The AQP9 gene contains a negative insulin response element, suggesting that it may be
modulated by insulin. Previously, we reported AQP9 overexpression in preeclamptic …

Amniotic fluid (AF) is created by the flow of fluid from the fetal lung and bladder and
reabsorbed in part by fetal swallowing and partly by the transfer across the amnion to the …

Objectives: Aquaporins are a family of water-selective channels that facilitate fluid movement
across cell membranes. Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have …

Background: The family of mammalian aquaporins (AQP) consists of 12 known members,
each with a specific tissue distribution and membrane localization pattern. AQP4 is the first …

Water is the major component of cells and tissues, and the movement of water across the
cell membrane is a fundamental property of life. Until the discovery of the first water channel …