Objective: Clinical response to antipsychotic drug treatment is highly variable, yet prognostic
biomarkers are lacking. The authors recently demonstrated that successful antipsychotic …

Background Schizophrenia and bipolar disorder share overlapping symptoms and risk
genes. Shared aberrant functional connectivity is hypothesized in both disorders and in …

Background Anatomical connectivity between the thalamus and cortex, including the
prefrontal cortex (PFC), is abnormal in schizophrenia. Overlapping phenotypes, including …

BACKGROUND: The theory that prefrontal cortex (PFC) dysfunction in schizophrenia leads
to excess subcortical dopamine has generated widespread interest because it provides a …

Importance Alterations in multiple neuroimaging phenotypes have been reported in
psychotic disorders. However, neuroimaging measures can be influenced by factors that are …

Abnormal neuroanatomic brain networks have been reported in schizophrenia, but their
characterization across patients with psychotic disorders, and their potential alterations in …

Background There is considerable evidence that the thalamus is abnormal in psychotic
disorders. Resting-state functional magnetic resonance imaging has revealed an intriguing …

Patients with first-episode psychosis experience psychotic symptoms for a mean of up to 2
years prior to initiation of treatment, and long duration of untreated psychosis (DUP) is …

Understanding the fundamental alterations in brain functioning that lead to psychotic
disorders remains a major challenge in clinical neuroscience. In particular, it is unknown …

Context Alterations in dopaminergic neurotransmission and function of the prefrontal cortex
are thought to be central to the pathophysiology of schizophrenia, but the relationship …