Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes

B Liu, L Li, G Liu, W Ding, W Chang, T Xu, X Ji… - Acta Pharmacologica …, 2021 - nature.com
Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits
a variety of pharmacological activities. In this study, we investigated the molecular …

Cardioprotective effects of baicalein on heart failure via modulation of Ca2+ handling proteins in vivo and in vitro

F Zhao, L Fu, W Yang, Y Dong, J Yang, S Sun, Y Hou - Life sciences, 2016 - Elsevier
Aims Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants
Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities …

Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism

AYH Woo, CHK Cheng, MMY Waye - Cardiovascular research, 2005 - academic.oup.com
Objectives: Baicalin and its aglycone baicalein are the major flavonoid components of the
root of Scutellaria baicalensis. Recent studies have shown that they can attenuate oxidative …

[HTML][HTML] Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase

M Shen, L Wang, G Yang, L Gao, B Wang, X Guo… - PLoS …, 2014 - journals.plos.org
Baicalin, the main active ingredient of the Scutellaria root, exerts anti-oxidant and anti-
apoptotic effects in cardiovascular diseases. However, the therapeutic mechanism of …

Biological properties of baicalein in cardiovascular system

Y Huang, SY Tsang, X Yao… - Current Drug Targets …, 2005 - ingentaconnect.com
The dried roots of Scutellaria baicalensis (S. baicalensis) Georgi (common name: Huangqin
in China) have been widely employed for many centuries in traditional Chinese herbal …

[HTML][HTML] Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy

M Xu, C Wan, S Huang, H Wang, D Fan, HM Wu… - Cell death & …, 2019 - nature.com
Autophagy is an endogenous protective process; the loss of autophagy could destabilize
proteostasis and elevate intracellular oxidative stress, which is critically involved in the …

Cucurbitacin B protects against pressure overload induced cardiac hypertrophy

Y Xiao, Z Yang, QQ Wu, XH Jiang… - Journal of cellular …, 2017 - Wiley Online Library
Lack of effective anti‐cardiac hypertrophy drugs creates a major cause for the increasing
prevalence of heart failure. In the present study, we determined the anti‐hypertrophy and …

Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways

L Ba, J Gao, Y Chen, H Qi, C Dong, H Pan, Q Zhang… - Phytomedicine, 2019 - Elsevier
Background Cardiac hypertrophy is an adaptive response of the myocardium to pressure or
volume overload. Recent evidences indicate that allicin can prevent cardiac hypertrophy …

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

MH Li, YJ Zhang, YH Yu, SH Yang, J Iqbal… - European journal of …, 2014 - Elsevier
Cardiac hypertrophy is a maladaptive change in response to pressure overload, and is also
an important risk for developing heart failure. Berberine is known to have cardioprotective …

Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and …

YM Lee, PY Cheng, LS Chim, CW Kung, SM Ka… - Journal of …, 2011 - Elsevier
Aim of the study To evaluate the protective effect of baicalein on myocardial dysfunction
caused by endotoxaemia in rats and to explore the possible mechanisms. Materials and …