[HTML][HTML] Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease

X Wang, X Zhou, B Uberseder, J Lee, CS Latimer… - Neurobiology of …, 2021 - Elsevier
AMP-activated protein kinase (AMPK) is a molecular sensor that is critical for the
maintenance of cellular energy homeostasis, disruption of which has been indicated in …

AMP‐activated protein kinase: a potential player in Alzheimer's disease

A Salminen, K Kaarniranta, A Haapasalo… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 118, 460–474. Abstract AMP‐activated protein kinase (AMPK)
stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy …

[HTML][HTML] Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice

X Zhou, W Yang, X Wang, T Ma - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
AMP-activated protein kinase (AMPK) functions as a molecular sensor that plays a critical
role in maintaining cellular energy homeostasis. Dysregulation of the AMPK signaling has …

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice

HR Zimmermann, W Yang, NP Kasica… - The Journal of …, 2020 - Am Soc Clin Investig
AMPK is a key regulator at the molecular level for maintaining energy metabolism
homeostasis. Mammalian AMPK is a heterotrimeric complex, and its catalytic α subunit …

AMPK in the brain: its roles in glucose and neural metabolism

R Muraleedharan, B Dasgupta - The FEBS Journal, 2022 - Wiley Online Library
The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …

AMPK-mediated regulation of neuronal metabolism and function in brain diseases

YJ Liu, Y Chern - Journal of neurogenetics, 2015 - Taylor & Francis
The AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a
key energy sensor in a wide variety of tissues. This kinase has been a major drug target for …

AMPK in neurodegenerative diseases

M Domise, V Vingtdeux - AMP-activated Protein Kinase, 2016 - Springer
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral
sclerosis are neurodegenerative disorders that are characterized by a progressive …

Therapeutic potential of AMP-activated protein kinase in Alzheimer's disease

X Wang, HR Zimmermann, T Ma - Journal of Alzheimer's …, 2019 - content.iospress.com
Currently there is no cure or effective disease-modifying therapy for Alzheimer's disease
(AD), the most common form of dementia that is becoming a global threat to public health. It …

The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects

L Xia, J Chen, J Huang, X Lin, J Jiang, T Liu, N Huang… - Heliyon, 2024 - cell.com
The AMP-activated protein kinase α (AMPKα) subunit is the catalytic subunit in the AMPK
complex, playing a crucial role in AMPK activation. It has two isoforms: AMPKα1 and …

Decreased Levels of Blood AMPK α1 but not AMPK α2 Isoform in Patients with Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study

X Wang, HR Zimmermann, SN Lockhart… - Journal of …, 2020 - content.iospress.com
Background: There is an urgent need to develop feasible biomarkers for diagnosis and
prognosis of Alzheimer's disease (AD). Mounting evidence implicates that dysregulation of …