Effects of polymers on the drug solubility and dissolution enhancement of poorly water-soluble rivaroxaban
The purpose of this study was to investigate the efficacy of hydrophilic polymers in a solid
dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB) …
dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB) …
Enhanced biopharmaceutical performance of rivaroxaban through polymeric amorphous solid dispersion
S Metre, S Mukesh, SK Samal, M Chand… - Molecular …, 2018 - ACS Publications
Rivaroxaban (RXB) is an orally active direct inhibitor of the activated serine protease Factor
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …
Enhanced oral bioavailability of Rivaroxaban-Loaded microspheres by optimizing the polymer and surfactant based on molecular interaction mechanisms
This study aimed to develop microspheres using water-soluble carriers and surfactants to
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
[HTML][HTML] Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs
Y Meng, F Tan, J Yao, Y Cui, Y Feng, Z Li… - International Journal of …, 2022 - Elsevier
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
Preparation and optimization of rivaroxaban by self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability and no food effect
X Xue, M Cao, L Ren, Y Qian, G Chen - Aaps Pharmscitech, 2018 - Springer
In this paper, a novel self-nanoemulsifying drug delivery system (SNEDDS) was used to
improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban …
improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban …
Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect
The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and
reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by …
reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by …
Rivaroxaban-loaded SLNs with treatment potential of deep vein thrombosis: in-vitro, in-vivo, and toxicity evaluation
X Luo, A Saleem, U Shafique, S Sarwar… - Pharmaceutical …, 2023 - Taylor & Francis
Objectives Rivaroxaban (RXB), a novel Xa inhibitor having groundbreaking therapeutic
potential. However, this drug is associated with few limitations, including its …
potential. However, this drug is associated with few limitations, including its …
Comparison of the physicochemical properties, aqueous solubility, and oral bioavailability of rivaroxaban-loaded high-pressure homogenised and Shirasu porous …
MJ Choi, JS Kim, H Yu, MR Woo, JE Choi… - Journal of Molecular …, 2022 - Elsevier
This study aimed to compare high-pressure homogenization (HPH) and Shirasu porous
glass (SPG) membrane emulsification for enhancing the oral bioavailability of rivaroxaban …
glass (SPG) membrane emulsification for enhancing the oral bioavailability of rivaroxaban …
Investigation of poor solubility of a salt-cocrystal hydrate: A case study of the common-ion effect in Betrixaban, an anticoagulant drug
R Devarapalli, A Indukuri, M Bollineni… - Molecular …, 2021 - ACS Publications
Achieving the desired solubility and dissolution of active pharmaceutical ingredients (APIs)
continues to be a big challenge in the pharmaceutical industry. In this regard …
continues to be a big challenge in the pharmaceutical industry. In this regard …
Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube
KT Moore, MA Krook, S Vaidyanathan… - … in drug development, 2014 - Wiley Online Library
Purpose Because some patients have difficulty swallowing a whole tablet, we investigated
the relative bioavailability of a crushed 20 mg rivaroxaban tablet and of 2 alternative crushed …
the relative bioavailability of a crushed 20 mg rivaroxaban tablet and of 2 alternative crushed …