Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
L Coultas, P Bouillet, KL Loveland, S Meachem… - The EMBO …, 2005 - embopress.org
The BH3‐only proteins of the Bcl‐2 family initiate apoptosis through the activation of Bax‐
like relatives. Loss of individual BH3‐only proteins can lead either to no phenotype, as in …
like relatives. Loss of individual BH3‐only proteins can lead either to no phenotype, as in …
[HTML][HTML] Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
P Bouillet, S Cory, LC Zhang, A Strasser, JM Adams - Developmental cell, 2001 - cell.com
Apoptosis is triggered when proapoptotic members of the Bcl-2 protein family bearing only
the BH3 association domain bind to Bcl-2 or its homologs and block their antiapoptotic …
the BH3 association domain bind to Bcl-2 or its homologs and block their antiapoptotic …
Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice
RS Akhtar, BJ Klocke, A Strasser… - … of Histochemistry & …, 2008 - journals.sagepub.com
Members of the Bcl-2 family include pro-and antiapoptotic proteins that regulate
programmed cell death of developing tissues and death in response to cellular damage. In …
programmed cell death of developing tissues and death in response to cellular damage. In …
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
J Hutcheson, JC Scatizzi, E Bickel, NJ Brown… - The Journal of …, 2005 - rupress.org
The proapoptotic members of the Bcl-2 family can be subdivided into members that contain
several Bcl-2 homology (BH) domains and those that contain only the BH3 domain …
several Bcl-2 homology (BH) domains and those that contain only the BH3 domain …
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
P Bouillet, D Metcalf, DCS Huang, DM Tarlinton… - Science, 1999 - science.org
Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share
only the BH3 domain with this family. Gene targeting in mice revealed important …
only the BH3 domain with this family. Gene targeting in mice revealed important …
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only
members activate the essential effectors Bax and Bak remains controversial. The indirect …
members activate the essential effectors Bax and Bak remains controversial. The indirect …
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation–induced apoptosis and deletion of autoreactive B cells
A Enders, P Bouillet, H Puthalakath, Y Xu… - The Journal of …, 2003 - rupress.org
During development, the stochastic process assembling the genes encoding antigen
receptors invariably generates B and T lymphocytes that can recognize self-antigens …
receptors invariably generates B and T lymphocytes that can recognize self-antigens …
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
WX Zong, T Lindsten, AJ Ross… - Genes & …, 2001 - genesdev.cshlp.org
The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce
apoptosis in wild-type cells and cells from either bax−/− or bak−/− animals. In contrast …
apoptosis in wild-type cells and cells from either bax−/− or bak−/− animals. In contrast …
Bim regulates BCR‐induced entry of B cells into the cell cycle
A Craxton, KE Draves, EA Clark - European journal of …, 2007 - Wiley Online Library
Abstract BH3‐only Bcl‐2 homologs are key regulators of the intrinsic apoptotic pathway. In
particular, Bim, is critical for mediating apoptosis of hematopoietic cells including B cells …
particular, Bim, is critical for mediating apoptosis of hematopoietic cells including B cells …
BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity
AJ Ross, SP Amy, PL Mahar, T Lindsten… - Developmental …, 2001 - Elsevier
Male mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due
to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and …
to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and …