Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …
Molecular therapeutic approaches for pediatric acute myeloid leukemia
Approximately two-thirds of children with acute myeloid leukemia (AML) are cured with
intensive multi-agent chemotherapy. However, refractory and relapsed AML remains a …
intensive multi-agent chemotherapy. However, refractory and relapsed AML remains a …
Comprehensive molecular understanding of pediatric acute myeloid leukemia
N Shiba - International Journal of Hematology, 2023 - Springer
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease with various genetic
abnormalities. Recent advances in genetic analysis have enabled the identification of …
abnormalities. Recent advances in genetic analysis have enabled the identification of …
The genomics of acute myeloid leukemia in children
SE Conneely, RE Rau - Cancer and Metastasis Reviews, 2020 - Springer
Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …
Straight to the point—the novel strategies to cure pediatric AML
M Lejman, I Dziatkiewicz, M Jurek - International Journal of Molecular …, 2022 - mdpi.com
Although the outcome has improved over the past decades, due to improved supportive
care, a better understanding of risk factors, and intensified chemotherapy, pediatric acute …
care, a better understanding of risk factors, and intensified chemotherapy, pediatric acute …
Molecularly targeted therapies for pediatric acute myeloid leukemia: progress to date
P Brown, FO Smith - Pediatric Drugs, 2008 - Springer
While acute myeloid leukemia (AML) is significantly less common than acute lymphoblastic
leukemia (ALL) in childhood, it is significantly more deadly with only half as many children …
leukemia (ALL) in childhood, it is significantly more deadly with only half as many children …
Molecular-targeted therapy of pediatric acute myeloid leukemia
P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood
leukemia cases. The overall survival of children with acute myeloid leukemia does not …
leukemia cases. The overall survival of children with acute myeloid leukemia does not …
Risk-stratified therapy for pediatric acute myeloid leukemia
D Tomizawa, SI Tsujimoto - Cancers, 2023 - mdpi.com
Simple Summary Owing to the 40-year worldwide efforts for improving diagnosis and
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …
[HTML][HTML] Epigenomic machinery regulating pediatric AML: Clonal expansion mechanisms, therapies, and future perspectives
U Chianese, C Papulino, W Megchelenbrink… - Seminars in Cancer …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy
CW Elgarten, R Aplenc - Current Opinion in Pediatrics, 2020 - journals.lww.com
Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …