Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches

N Tosic, I Marjanovic, J Lazic - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …

Molecular therapeutic approaches for pediatric acute myeloid leukemia

SK Tasian, JA Pollard, R Aplenc - Frontiers in oncology, 2014 - frontiersin.org
Approximately two-thirds of children with acute myeloid leukemia (AML) are cured with
intensive multi-agent chemotherapy. However, refractory and relapsed AML remains a …

Comprehensive molecular understanding of pediatric acute myeloid leukemia

N Shiba - International Journal of Hematology, 2023 - Springer
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease with various genetic
abnormalities. Recent advances in genetic analysis have enabled the identification of …

The genomics of acute myeloid leukemia in children

SE Conneely, RE Rau - Cancer and Metastasis Reviews, 2020 - Springer
Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …

Straight to the point—the novel strategies to cure pediatric AML

M Lejman, I Dziatkiewicz, M Jurek - International Journal of Molecular …, 2022 - mdpi.com
Although the outcome has improved over the past decades, due to improved supportive
care, a better understanding of risk factors, and intensified chemotherapy, pediatric acute …

Molecularly targeted therapies for pediatric acute myeloid leukemia: progress to date

P Brown, FO Smith - Pediatric Drugs, 2008 - Springer
While acute myeloid leukemia (AML) is significantly less common than acute lymphoblastic
leukemia (ALL) in childhood, it is significantly more deadly with only half as many children …

Molecular-targeted therapy of pediatric acute myeloid leukemia

P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood
leukemia cases. The overall survival of children with acute myeloid leukemia does not …

Risk-stratified therapy for pediatric acute myeloid leukemia

D Tomizawa, SI Tsujimoto - Cancers, 2023 - mdpi.com
Simple Summary Owing to the 40-year worldwide efforts for improving diagnosis and
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …

[HTML][HTML] Epigenomic machinery regulating pediatric AML: Clonal expansion mechanisms, therapies, and future perspectives

U Chianese, C Papulino, W Megchelenbrink… - Seminars in Cancer …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy

CW Elgarten, R Aplenc - Current Opinion in Pediatrics, 2020 - journals.lww.com
Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …