National survey of the in vitro spectrum of piperacillin-tazobactam tested against more than 40,000 aerobic clinical isolates from 236 medical centers

EJ Baron, RN Jones - Diagnostic microbiology and infectious disease, 1995 - Elsevier
Hospital microbiology laboratories from 41 states participated in a bacterial antimicrobial
susceptibility study comparing in vitro results generated by the standardized disk diffusion …

Could an optimized joint Pharmacokinetic/Pharmacodynamic target attainment of continuous infusion Piperacillin-Tazobactam be a Valuable innovative Approach for …

M Gatti, M Rinaldi, T Tonetti, A Siniscalchi, P Viale… - Antibiotics, 2023 - mdpi.com
(1) Background: Piperacillin-tazobactam represents the first-line option for treating infections
caused by full-or multi-susceptible Enterobacterales and/or Pseudomonas aeruginosa in …

Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis

SC Mueller, J Majcher-Peszynska… - Antimicrobial agents …, 2002 - Am Soc Microbiol
The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive
care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination …

Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam

NA Kuck, NV Jacobus, PJ Petersen… - Antimicrobial Agents …, 1989 - Am Soc Microbiol
Tazobactam (YTR-830H), a novel beta-lactamase inhibitor, was compared with clavulanic
acid and sulbactam for enhancement of the activity of piperacillin against beta-lactamase …

Comparative susceptibility profile of piperacillin/tazobactam against anaerobic bacteria

PC Appelbaum - Journal of Antimicrobial Chemotherapy, 1993 - academic.oup.com
Current data are summarized on the comparative susceptibility of Gram-positive and Gram-
negative anaerobic bacteria to piperacillin/tazobactam and other anti-anaerobe agents. For …

Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile

CB Landersdorfer, JB Bulitta… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

Piperacillin population pharmacokinetics in critically ill adults during sustained low-efficiency dialysis

S Kanji, JA Roberts, J Xie, A Alobaid… - Annals of …, 2018 - journals.sagepub.com
Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

An improved high‐performance liquid chromatographic method with a solid‐phase extraction for the determination of piperacillin and tazobactam: application to …

C Xia, Y Xiong, G Wang - Biomedical Chromatography, 2007 - Wiley Online Library
An improved HPLC method was developed for the determination of piperacillin and
tazobactam in human plasma and pharmacokinetic study in Chinese healthy volunteers …

Comparative activity of piperacillin/tazobactam against 5625 isolates from hospitalised patients

L Verbist, J Verhaegen, C Wounters… - Journal of …, 1996 - academic.oup.com
The comparative activities of piperacillin/tazobactam and other antibiotics against 5625
Gram-negative and Gram-positive bactena freshly isolated from hospitalized patients was …

Pharmacokinetics of piperacillin, tazobactam and its metabolite in renal impairment.

H Derendorf, T Dalla Costa - International journal of clinical …, 1996 - europepmc.org
The pharmacokinetics of piperacillin, tazobactam and its M1 metabolite were studied in
patients with various degrees of renal impairment after single and multiple intravenous …