We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

There is a need to develop effective countermeasures for Yersinia pestis, the etiologic agent
of plague and a potential bioterrorism agent. Salmonella and Shigella spp. deleted in the …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

Chapter 7 Signature-Tagged Mutagenesis of Yersinia pestis Page 1 Chapter 7 Signature-Tagged
Mutagenesis of Yersinia pestis Petra CF OYSTON 1 , Andrey V. KARLYSHEV 2 , Brendan W …

Yersinia pestis, the causative agent of plague, can be transmitted by infected flea bite or
inhaled aerosol. Both routes of infection have a high mortality rate, and pneumonic …

Yersinia pestis is able to survive and replicate within murine macrophages. However, the
mechanism by which Y. pestis promotes its intracellular survival is not well understood. To …

The pathogenesis of infection with Yersinia pestis, the causative agent of plague, was
examined following subcutaneous infection of BALB/c mice with a fully virulent strain …

Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y.
pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll …

The ppGpp molecule is part of a highly conserved regulatory system for mediating the
growth response to various environmental conditions. This mechanism may represent a …

We employed Murine GeneChips to delineate the global transcriptional profiles of the livers,
lungs, and spleens in a mouse pneumonic plague infection model with wild-type (WT) Y …