Mathematical modeling is an essential tool for the comprehensive understanding of cell
metabolism and its interactions with the environmental and process conditions. Recent …

Accurate determination of physiological states of cellular metabolism requires detailed
information about metabolic fluxes, metabolite concentrations and distribution of enzyme …

Background Advances in bioinformatic techniques and analyses have led to the availability
of genome-scale metabolic reconstructions. The size and complexity of such networks often …

The quantitative analysis of biochemical reactions and metabolites is at frontier of biological
sciences. The recent availability of high-throughput technology data sets in biology has …

Many important problems in cell biology arise from the dense nonlinear interactions
between functional modules. The importance of mathematical modelling and computer …

Genome-scale metabolic networks provide a comprehensive structural framework for
modeling genotype-phenotype relationships through flux simulations. The solution space for …

Metabolic engineering serves as an integrated approach to design new cell factories by
providing rational design procedures and valuable mathematical and experimental tools …

Genome-scale metabolic network reconstructions in microorganisms have been formulated
and studied for about 8 years. The constraint-based approach has shown great promise in …

Genome-scale metabolic networks have been reconstructed for several organisms. These
metabolic networks provide detailed information about the metabolism inside the cells …

Constraint-based, genome-scale metabolic models are an essential tool to guide metabolic
engineering. However, they lack the detail and time dimension that kinetic models with …