Background Maternal obesity alters oocytes and subsequent fetal metabolism. An
increasing number of studies have shown that the endoplasmic reticulums (ER) or …

Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …

Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial
dysfunction plays a central role here, and most often inbred mouse models are used to study …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

Obesity affects oocyte mitochondrial functions and reduces oocyte quality and fertility.
Obesity may also increase the risk of metabolic disorders in the offspring. Children are likely …

Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Overweight or obese women seeking pregnancy is becoming increasingly common. Human
maternal obesity gives rise to detrimental effects during reproduction. Emerging evidence …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …