Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

An understanding of underlying mechanisms involved in the activation of HIF‐1 in response
to both hypoxic stress and oncogenic signals has important implications for how these …

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic
response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a …

Most solid tumors develop regions of hypoxia as they grow and outstrip their blood supply. In
order to survive in the stressful hypoxic environment, tumor cells have developed a …

Abstract Dewhirst, MW Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and
Oxidative Stress. This Failla Lecture focused on the inter-relationships between tumor …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Abstract Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and
metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …