Pituitary adenoma form via a process that is thought to be derived from the clonal expansion
of single abnormal cells owing to somatic genetic mutations or chromosomal abnormalities …

Investigation of the epigenome of sporadic pituitary tumours is providing a more detailed
understanding of aberrations that characterise this tumour type. Early studies, in this and …

The majority of pituitary adenomas are trophically stable and change relatively little in size
over many years. A comparatively small proportion behave more aggressively and come to …

Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

Object. This study was conducted to determine whether comparative genomic hybridization
(CGH) is a more sensitive method for detecting genetic aberrations than other tests currently …

Purpose The molecular pathogenesis of growth hormone-secreting pituitary adenomas is
not fully understood. Cytogenetic alterations might serve as alternative driver events in …

Context.—The sellar region is the site of frequent pathology. The pituitary is affected by a
large number of pathologic entities arising from the gland itself and from adjacent …

Twenty‐four pituitary adenomas, both the sporadic type (n= 18) and the type arising in
association with either multiple endocrine neoplasia, type 1 (MEN1; n= 2), or Carney …

Genetic mutations involving oncogenes or tumor suppressor genes are relatively uncommon
in human sporadic pituitary tumors. Instead, increasing evidence has highlighted frequent …

The clinical characteristics of growth hormone (GH)-producing pituitary adenomas/
somatotroph pituitary neuroendocrine tumors (GHomas/somatotroph PitNETs) vary across …