In immune-mediated chronic inflammation the balance between pro-inflammatory and anti-
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …

A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor
synthesis and T-and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …

Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively
regulates all cell types involved in the initiation, propagation, and resolution of inflammation …

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays a critical role in orchestrating immune and inflammatory responses, and it is essential …

Four Janus kinases (JAKs)(JAK1, JAK2, JAK3, TYK2) and seven signal transducers and
activators of transcription (STATs)(STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B …

The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Pro-inflammatory cytokine and anabolic growth factor-mediated activation of the Janus
kinase/Signal Transducers and Activators of Transcription (JAK/STAT), Stress-activated …