[HTML][HTML] Discovery of small molecules that activate RNA methylation through cooperative binding to the METTL3-14-WTAP complex active site
S Selberg, D Blokhina, M Aatonen, P Koivisto… - Cell reports, 2019 - cell.com
Chemical modifications of RNA provide an additional, epitranscriptomic, level of control over
cellular functions. N-6-methylated adenosines (m6As) are found in several types of RNA …
cellular functions. N-6-methylated adenosines (m6As) are found in several types of RNA …
A birds'‐eye view of the activity and specificity of the mRNA m6A methyltransferase complex
D Garcias Morales, JL Reyes - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Appropriate control of the transcriptome is essential to regulate different aspects of gene
expression during development and in response to environmental stimuli. Fast accumulating …
expression during development and in response to environmental stimuli. Fast accumulating …
Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
EVA Schöller, F Weichmann, T Treiber, S Ringle… - Rna, 2018 - rnajournal.cshlp.org
N 6-methyladenine (m6A) is found on many eukaryotic RNAs including mRNAs. m6A
modification has been implicated in mRNA stability and turnover, localization, or translation …
modification has been implicated in mRNA stability and turnover, localization, or translation …
[HTML][HTML] The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
Q Huang, J Mo, Z Liao, X Chen, B Zhang - Cell Death & Disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …
[HTML][HTML] Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases
Summary N 6-methyladenosine (m 6 A) is a prevalent, reversible chemical modification of
functional RNAs and is important for central events in biology. The core m 6 A writers are …
functional RNAs and is important for central events in biology. The core m 6 A writers are …
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Abstract N 6-methyladenosine (m6A) is the most prevalent and reversible internal
modification in mammalian messenger and noncoding RNAs. We report here that human …
modification in mammalian messenger and noncoding RNAs. We report here that human …
Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
Chemical modifications of RNA have essential roles in a vast range of cellular processes,,. N
6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long …
6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long …
The RNA m6A writer METTL14 in cancers: Roles, structures, and applications
H Zhou, K Yin, Y Zhang, J Tian, S Wang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is the most abundant and diverse epigenetic
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …
[HTML][HTML] Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Abstract The methyltransferase like 3 (METTL3)-containing methyltransferase complex
catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; …
catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; …