Propofol is an intravenous anesthetic currently available for clinical investigative use. The
intraoperative and postoperative effects of propofol were compared to methohexital when …

Background Many drugs are removed by the lung. The pulmonary uptake of one drug can
be inhibited when a second, highly accumulated drug is administered parenterally or as a …

Propofol (2, 6diisopropylphenol) in soya bean egg phospholipid emulsion is the newest
intravenous anaesthetic agent to become available for clinical use [l-41. The …

The pharmacokinetic and pharmacodynamic interactions between opioids and propofol
increasingly have been described and used in clinical practice. It is now known that propofol …

A computer-controlled infusion of propofol designed to achieve a target blood concentration
of propofol 3 μg ml− 1 was used to investigate the possibility of an interaction between …

The disposition of propofol was studied in women undergoing elective Caesarean section.
Indices of maternal recovery and neonatal assessment were correlated with venous …

We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10
patients with cirrhosis. Anaesthesia was induced within 3–4 min during administration of an …

1. Pharmacokinetic data for propofol, a new intravenous anaesthetic agent, indicate that
there may be extensive extrahepatic clearance. This was investigated during intravenous …

Differences in the pharmacokinetics of propofol between male and female patients during
and after continuous infusion have not been described in detail in patients aged 65 yr and …

To investigate clinically important hypotension and bradycardia after induction of anesthesia
with propofol, we analyzed data from a Phase IV stepwise study involving 25,981 patients …