β-Amyloid peptides are believed to play an essential role in Alzheimer's disease (AD), due
to their sedimentation in the form of β-amyloid aggregates in the brain of AD-patients, and …

We have studied the dimer of amyloid beta peptide Aβ of 40 residues by means of all-atom
replica exchange molecular dynamics. The Aβ-dimers have been found to be the smallest …

The 25–35 fragment of the Alzheimer amyloid β (Aβ) peptide is a naturally occurring
proteolytic by-product that retains the toxicity of its larger, better-known counterpart, Aβ (1 …

The β amyloid (Aβ) peptide aggregates to form β-rich structures that are known to trigger
Alzheimer's disease. Experiments suggest that an α-helical intermediate precedes the …

Oligomers of A β peptides are suspected as the underlying cause of Alzheimer disease.
Knowledge of their structural properties could therefore lead to a deeper understanding of …

Amyloid oligomers and plaques are composed of multiple chemically identical proteins.
Therefore, one of the first fundamental problems in the characterization of structures from …

In this paper, all-atom molecular dynamics simulations in explicit solvent are used to
investigate the structural and dynamical determinants of the α-helical to β-hairpin …

In this study, all-atom 50 ns molecular dynamics simulations are performed on the full-length
amyloid beta (Aβ) monomers (WT-Aβ (1− 40) and WT-Aβ (1− 42)) and their oxidized forms …

Accumulation of the amyloid beta (Aβ) peptide in the brain is responsible for debilitating
neurodegenerative diseases, such as Alzheimer's disease (AD). We have carried out …

Recent experiments indicate a connection between the structure of amyloid aggregates and
their cytotoxicity as related to neurodegenerative diseases. Of particular interest is the Iowa …