Increasing evidence suggests that soluble aggregates of amyloid-β (Aβ) initiate the
neurotoxicity that eventually leads to dementia in Alzheimer's disease. Knowledge on …

The amyloid β peptide (Aβ), composed of 40 or 42 amino acids, is a critical component in the
etiology of the neurodegenerative Alzheimer disease. Aβ is prone to aggregate and forms …

Metastable oligomeric and protofibrillar forms of amyloidogenic proteins have been
implicated as on-pathway assembly intermediates in amyloid formation and as the major …

The amyloid β-protein (Aβ) is a seminal neuropathic agent in Alzheimer's disease (AD).
Recent evidence points to soluble Aβ oligomers as the probable neurotoxic species. Among …

Abrupt aggregation of amyloid beta (Aβ) peptide is strongly associated with Alzheimer's
disease. In this study, we used atomic force microscopy–infrared (AFM-IR) spectroscopy to …

The biochemistry of amyloid proteins has been a fascinating and important area of research
because of its contribution to our understanding of protein folding dynamics and assembly …

Soluble oligomers and protofibrils are widely thought to be the toxic forms of the Aβ42
peptide associated with Alzheimer's disease. We have investigated the structure and …

The progressive deposition of the amyloid β peptide (Aβ) in fibrillar form is a key feature in
the development of the pathology in Alzheimer's disease (AD). We have characterized the …

Neurotoxic assemblies of the amyloid β‐protein (Aβ) have been linked strongly to the
pathogenesis of Alzheimer's disease (AD). Here, we sought to monitor the earliest step in Aβ …

Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various
neurodegenerative diseases. This process involves protein assembly into oligomeric …