Soluble oligomers and protofibrils of the Aβ42 peptide are neurotoxic intermediates in the
conversion of monomeric Aβ42 into the amyloid fibrils associated with Alzheimer's disease …

Amyloid fibrils comprising primarily the peptides Aβ40 and Aβ42 are a defining feature of the
Alzheimer's disease (AD) brain, and convergent evidence suggests that the process of their …

Alzheimer's disease is a neurodegenerative disorder that is characterized by the cerebral
deposition of amyloid fibrils formed by Aβ peptide. Despite their prevalence in Alzheimer's …

Amyloidogenic deposits that accumulate in brain tissue with the progression of Alzheimer's
disease contain large amounts of the amyloid β-peptide. A small fragment of this peptide …

According to the amyloid hypothesis, the pathogenesis of Alzheimer's disease is triggered
by the oligomerization and aggregation of the amyloid-β (Aβ) peptide into protein plaques …

The formation of amyloid fibrils, protofibrils and oligomers from the β-amyloid (Aβ) peptide
represents a hallmark of Alzheimer's disease. Aβ-peptide-derived assemblies might be …

Insight into how amyloid β (Aβ) aggregation occurs in vivo is vital for understanding the
molecular pathways that underlie Alzheimer's disease and requires new techniques that …

Oligomeric states of the amyloid β-protein (Aβ) appear to be causally related to Alzheimer's
disease (AD). Recently, two familial mutations in the amyloid precursor protein gene have …

Understanding the structural and assembly dynamics of the amyloid β-protein (Aβ) has
direct relevance to the development of therapeutic agents for Alzheimer disease. To …

Recent research has focused on soluble oligomeric assemblies of the 42 amino acid isoform
of the amyloid‐beta peptide (Aβ42) as the proximal cause of neuronal injury, synaptic loss …