Diffusible subfibrillar aggregates of amyloid proteins are potent neurotoxins and primary
suspects in amyloid diseases including Alzheimer's disease. Despite widespread interest …

Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer's disease.
Aβ42, which is only two amino acids longer than Aβ40, is particularly pathogenic. Why this is …

The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering
from Alzheimer's disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal …

One hundred years ago, Alois Alzheimer observed a relationship between cognitive
impairment and the presence of plaque in the brains of patients suffering from the disease …

We describe electron microscopy (EM), scanning transmission electron microscopy (STEM),
and solid-state nuclear magnetic resonance (NMR) measurements on amyloid fibrils formed …

Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of
amyloid plaques in the brain. This amyloid primarily contains amyloid-β (Aβ), a 39-to 43-aa …

Proteins adopt an amazing array of sequence-dependent struc-tures that enable them to
perform the many chemical functions critical to life. Over the past decade, however, it has …

Amino acid cross-strand pairing interactions along a β-sheet surface have been implicated
in protein β-structural assembly and stability, yet the relative contributions have been difficult …

AD (Alzheimer's disease) is linked to Aβ (amyloid β-peptide) misfolding. Studies
demonstrate that the level of soluble Aβ oligomeric forms correlates better with the …

Limited solubility and precipitation of amyloidogenic sequences such as the Alzheimer
peptide (β-AP) are major obstacles to a molecular understanding of protein fibrillation and …