Two‐photon microscopy is providing literal insight into the cellular dynamics of lymphoid
organs and, guided by analysis of three‐dimensional images, into mechanisms that underlie …

The immune system is the most diffuse cellular system in the body. Accordingly, long-range
migration of cells and short-range communication by local chemical signaling and by cell …

New preparations, fluorescent probes and imaging techniques are providing the means to
observe the behavior of cells in the tissue environment of lymphoid organs. In particular …

The functioning of the immune system depends upon exquisitely choreographed
interactions between its cellular constituents. Two-photon microscopy now enables us to …

A key to understanding the functioning of the immune system is to define the mechanisms
that facilitate directed lymphocyte migration to and within tissues. The recent development of …

Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact
with antigen-presenting cells. Visualization of these processes has previously been limited …

The recent application of two-photon microscopy to the visualization of T cell movement has
presented trajectories of individual T cells within lymphoid organs both in the presence and …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Cellular interactions in lymphoid organs initiate the immune response and determine its
outcome. Using two-photon microscopy in the lymph node, several groups have begun to …

Adaptive immunity is initiated by T cell recognition of foreign peptides presented on dendritic
cells (DCs) by major histocompatibility molecules. These interactions take place in …