Identification of key target genes and biological pathways in multiple sclerosis brains using microarray data obtained from the Gene Expression Omnibus database

W Zheng, Y Chen, H Chen, W Xiao, YJ Liang… - Neurological …, 2018 - Taylor & Francis
Objective: The purpose of this study was to investigate critical genes in multiple sclerosis
(MS) using microarray data from brain tissue in MS. Materials: The expression profile data …

Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets

MI Jansen, A Castorina - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS)
whose aetiology is only partly understood. Investigating the intricate transcriptional changes …

Microarray gene expression profiling analysis combined with bioinformatics in multiple sclerosis

M Liu, X Hou, P Zhang, Y Hao, Y Yang, X Wu… - Molecular biology …, 2013 - Springer
Multiple sclerosis (MS) is the most prevalent demyelinating disease and the principal cause
of neurological disability in young adults. Recent microarray gene expression profiling …

Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis

SU Kumar, A Datta, R Gnanasambandan… - Advances in protein …, 2022 - Elsevier
Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific
demyelinating disorder, known to affect the central nervous system (CNS). While genetic …

Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis

N Safari-Alighiarloo, M Rezaei-Tavirani, M Taghizadeh… - PeerJ, 2016 - peerj.com
Background The involvement of multiple genes and missing heritability, which are dominant
in complex diseases such as multiple sclerosis (MS), entail using network biology to better …

Identification of key genes associated with multiple sclerosis based on gene expression data from peripheral blood mononuclear cells

Z Shang, W Sun, M Zhang, L Xu, X Jia, R Zhang, S Fu - PeerJ, 2020 - peerj.com
The aim of this study was to identify the potential key candidate genes of multiple sclerosis
(MS) and uncover mechanisms in MS. We combined data from the microarray expression …

Gene expression profiling in multiple sclerosis brain

R Dutta, BD Trapp - Neurobiology of disease, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and the leading cause of non-traumatic neurological disability in young …

Dense module searching for gene networks associated with multiple sclerosis

AM Manuel, Y Dai, LA Freeman, P Jia, Z Zhao - BMC Medical Genomics, 2020 - Springer
Background Multiple sclerosis (MS) is a complex disease in which the immune system
attacks the central nervous system. The molecular mechanisms contributing to the etiology …

Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis

X Chen, H Hou, H Qiao, H Fan, T Zhao, M Dong - Biological Research, 2021 - Springer
Background Multiple sclerosis (MS) is a central nervous system disease with a high
disability rate. Modern molecular biology techniques have identified a number of key genes …

[HTML][HTML] cDNA microarray and bioinformatic analysis for the identification of key genes in Alzheimer's disease

C Gu, T Shen - International Journal of Molecular …, 2014 - spandidos-publications.com
In this study, gene expression profiles in peripheral blood monocytes from patients with
Alzheimer's disease (AD) or mild cognitive impairment (MCI) were compared with those of …