The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies

J Xu, L Li, P Shi, H Cui, L Yang - International Journal of Molecular …, 2022 - mdpi.com
B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Knockdown BMI1 expression inhibits proliferation and invasion in human bladder cancer T24 cells

W Liang, D Zhu, X Cui, J Su, H Liu, J Han… - Molecular and Cellular …, 2013 - Springer
B cell-specific moloney murine leukemia virus integration site 1 (BMI1) is a transcriptional
repressor of polycomb repressive complex 1, which is involved in the proliferation …

Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma

IB Engelsen, M Mannelqvist, IM Stefansson… - British journal of …, 2008 - nature.com
We studied the expression of polycomb group (PcG) protein BMI-1 in a large population-
based patient series of endometrial carcinomas in relation to clinical and molecular …

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in/10.3892/or. 2022.8352

J Yu, L Chen, Z Bao, Y Liu, G Liu… - Oncology …, 2020 - spandidos-publications.com
Endometrial adenocarcinoma is one of the most common types of gynecological
malignancies and its incidence and mortality rates are increasing. Due to tumor recurrence …

Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study

K Vrzalikova, J Skarda, J Ehrmann, PG Murray… - Journal of cancer …, 2008 - Springer
Abstract Purpose Bmi-1 is a Polycomb group member which participates in many
physiological processes as well as in a wide spectrum of cancers. The aim of this study was …

Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in …

M Sasaki, J Yamaguchi, H Ikeda, K Itatsu, Y Nakanuma - Human pathology, 2009 - Elsevier
Polycomb-group proteins Bmi1 is regarded as a “stemness” gene involved in the
maintenance of stem cells, malignant transformation, and biologic aggressiveness of several …

BMI1 gene expression in myeloid leukemias and its impact on prognosis

NS Saudy, IM Fawzy, E Azmy, EF Goda… - Blood Cells, Molecules …, 2014 - Elsevier
Background BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It
plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent …

Clinicopathological and prognostic significance of Bmi‐1 expression in human cervical cancer

L Min, S DONG‐XIANG… - Acta obstetricia et …, 2011 - Wiley Online Library
Objective. To investigate the clinical significance of Bmi‐1 expression as a prognostic
marker for cervical cancer. Design. Retrospectively collected data from a population‐based …

Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer

JH Kim, SY Yoon, SH Jeong, SY Kim, SK Moon, JH Joo… - The Breast, 2004 - Elsevier
The modulation of Bmi-1 is observed in several tumor tissues, and its heightened protein
level is suspected to be involved in tumorigenesis by acting as a transcriptional repressor in …

BMI1, a new target of CK2α

S Banerjee Mustafi, PK Chakraborty, SKD Dwivedi… - Molecular Cancer, 2017 - Springer
Background The polycomb group protein, BMI1 plays important roles in chromatin
modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such …