Structural variation of chondroitin sulfate and its roles in the central nervous system

N Maeda - Central Nervous System Agents in Medicinal …, 2010 - ingentaconnect.com
Chondroitin sulfate is popular in the field of neuroscience, because the treatment of nervous
tissues with chondroitinase ABC, which degrades chondroitin sulfate up to unsaturated …

Chondroitin/dermatan sulfate in the central nervous system

K Sugahara, T Mikami - Current opinion in structural biology, 2007 - Elsevier
In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major
barrier-forming molecules, influence cell migration patterns and axon pathfinding. By …

Chondroitin sulfate: a key molecule in the brain matrix

JCF Kwok, P Warren, JW Fawcett - … journal of biochemistry & cell biology, 2012 - Elsevier
Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and
glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG) …

Chondroitin sulfates and their binding molecules in the central nervous system

L Djerbal, H Lortat-Jacob, JCF Kwok - Glycoconjugate journal, 2017 - Springer
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central
nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different …

A chondroitin sulfate small molecule that stimulates neuronal growth

SE Tully, R Mabon, CI Gama, SM Tsai… - Journal of the …, 2004 - ACS Publications
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell
division, neuronal development, and spinal cord injury. Here, we report the synthesis and …

Evaluation of chondroitin sulfate bioactivity in hippocampal neurones and the astrocyte cell line U373: Influence of position of sulfate groups and charge density

A Rapp, N Brandl, N Volpi… - Basic & clinical …, 2005 - Wiley Online Library
Chondroitin sulfates are linear polysaccharides of alternating glucuronic acid and N‐
acetylgalactosamine, sulfated in varying positions. They form the extracellular framework …

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

H Wang, Y Katagiri, TE McCann… - Journal of cell …, 2008 - journals.biologists.com
Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with
diversity and complexity based upon the length, composition and charge distribution of the …

Functions of chondroitin sulfate and heparan sulfate in the developing brain

N Maeda, M Ishii, K Nishimura, K Kamimura - Neurochemical research, 2011 - Springer
Chondroitin sulfate and heparan sulfate proteoglycans are major components of the cell
surface and extracellular matrix in the brain. Both chondroitin sulfate and heparan sulfate …

Chondroitin sulfate-D promotes neurite outgrowth by acting as an extracellular ligand for neuronal integrin αVβ3

M Shida, T Mikami, J Tamura, H Kitagawa - Biochimica et Biophysica Acta …, 2019 - Elsevier
Background Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix
components in the central nervous system (CNS) and can exert positive or negative …

Targeting inhibitory chondroitin sulphate proteoglycans to promote plasticity after injury

JCF Kwok, JP Heller, RR Zhao, JW Fawcett - Axon growth and …, 2014 - Springer
Chondroitin sulphate proteoglycans (CSPGs) are one of the major families of inhibitory
extracellular matrix molecules in the central nervous system. The expression of various …