T cell–derived IL-22 amplifies IL-1β–driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes
Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology
leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced …
leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced …
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …
including obesity and its associated metabolic syndrome. In this paper, we show that the …
IL-17 in obesity and adipogenesis
M Ahmed, SL Gaffen - Cytokine & growth factor reviews, 2010 - Elsevier
The pro-inflammatory cytokine interleukin (IL)-17 (also known as IL-17) has been associated
with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic …
with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic …
IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors
M Ahmed, SL Gaffen - Cytokine, 2013 - Elsevier
IL-17 is an inflammatory cytokine associated with anti-microbial host defense and
pathogenesis of autoimmune diseases. Obesity is considered to be an inflammatory …
pathogenesis of autoimmune diseases. Obesity is considered to be an inflammatory …
Interleukin‐15 contributes to the regulation of murine adipose tissue and human adipocytes
NG Barra, S Reid, R MacKenzie, G Werstuck… - …, 2010 - Wiley Online Library
An alarming global rise in the prevalence of obesity and its contribution to the development
of chronic diseases is a serious health concern. Recently, obesity has been described as a …
of chronic diseases is a serious health concern. Recently, obesity has been described as a …
Increased adipose tissue expression of IL‐18R and its ligand IL‐18 associates with inflammation and insulin resistance in obesity
R Ahmad, R Thomas, S Kochumon… - Immunity, inflammation …, 2017 - Wiley Online Library
Introduction The proinflammatory cytokine IL‐18 is involved in the pathogenesis of metabolic
syndrome. While the changes in IL‐18 are known, IL‐18R expression and relationship with …
syndrome. While the changes in IL‐18 are known, IL‐18R expression and relationship with …
Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes
JH Shin, DW Shin, M Noh - Biochemical pharmacology, 2009 - Elsevier
The immune system is closely linked to human metabolic diseases. Serum levels of IL-6
increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin …
increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin …
[HTML][HTML] Pathogenic role of IL-17-producing immune cells in obesity, and related inflammatory diseases
M Chehimi, H Vidal, A Eljaafari - Journal of clinical medicine, 2017 - mdpi.com
Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in
obese individuals are the former site of progressive infiltration by pro-inflammatory immune …
obese individuals are the former site of progressive infiltration by pro-inflammatory immune …
Interleukin‐15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
NG Barra, MV Chew, AC Holloway… - Diabetes, Obesity and …, 2012 - Wiley Online Library
The prevalence of metabolic diseases associated with obesity, such as type 2 diabetes,
continues to rise along with obesity rates. Recently, obesity has been described as an …
continues to rise along with obesity rates. Recently, obesity has been described as an …
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
J Ye - Frontiers of medicine, 2015 - Springer
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose
tissue function. Although this view is supported by a large body of literature, it has been …
tissue function. Although this view is supported by a large body of literature, it has been …