Upregulation of MTHFD2 is associated with PD-L1 activation in bladder cancer via the PI3K/AKT pathway
X Deng, X Liu, B Hu, J Liu, B Fu… - … Journal of Molecular …, 2022 - spandidos-publications.com
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been implicated in the etiology
of various human malignant tumors; however, its exact role in bladder cancer (BC) remains …
of various human malignant tumors; however, its exact role in bladder cancer (BC) remains …
MTHFD2 promotes PD‐L1 expression via activation of the JAK/STAT signalling pathway in bladder cancer
L Li, Y Zhang, W Hu, F Zou, J Ning… - Journal of Cellular …, 2023 - Wiley Online Library
Although combination chemotherapy is widely used for bladder cancer (BC) treatment, the
recurrence and progression rates remain high. Therefore, novel therapeutic targets are …
recurrence and progression rates remain high. Therefore, novel therapeutic targets are …
[HTML][HTML] Expression and role of methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L) in bladder cancer
Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino
acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts …
acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts …
MTHFD2 is a potential oncogene for its strong association with poor prognosis and high level of immune infiltrates in urothelial carcinomas of bladder
L Zhu, X Liu, W Zhang, H Hu, Q Wang, K Xu - BMC cancer, 2022 - Springer
Background The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+
dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to …
dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to …
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human …
N Sial, JU Rehman, S Saeed, M Ahmad… - Bioscience …, 2022 - portlandpress.com
Background: Defects in methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L)
expression have earlier been examined in only a few human cancers. Objectives: Multi …
expression have earlier been examined in only a few human cancers. Objectives: Multi …
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway
Q Li, F Yang, X Shi, S Bian, F Shen, Y Wu… - FEBS open …, 2021 - Wiley Online Library
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme located in
the mitochondria. MTHFD2 has been reported to be overexpressed in several malignant …
the mitochondria. MTHFD2 has been reported to be overexpressed in several malignant …
Down‐regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle‐related genes
C Yu, L Yang, M Cai, F Zhou, S Xiao… - Journal of cellular …, 2020 - Wiley Online Library
Abstract Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme
located in the mitochondria. It has been reported to be overexpressed in several …
located in the mitochondria. It has been reported to be overexpressed in several …
[HTML][HTML] NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis
L Zhao, Z Cheng, Z Lu, J Jin - Translational Cancer Research, 2021 - ncbi.nlm.nih.gov
Background NAD-dependent methylenetetrahydrofolate dehydrogenase catalyzes the
conversion of 10-formyltetrahydrofolate to formate in embryonic and adult mammalian …
conversion of 10-formyltetrahydrofolate to formate in embryonic and adult mammalian …
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma
J Chen, J Yang, Q Xu, Z Wang, J Wu, L Pan… - Bioscience …, 2021 - portlandpress.com
Liver hepatocellular carcinoma (LIHC) is one of the most frequently occurring primary
malignant liver tumors and seriously harms people's health in the world …
malignant liver tumors and seriously harms people's health in the world …
MTHFD1L knockdown diminished cells growth in papillary thyroid cancer
D Yi, C Jiang, R Wang, X Lu, J Sang, L Su - Tissue and Cell, 2022 - Elsevier
Abstract Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like (MTHFD1L)
is a mitochondrial enzyme involved in the synthesis of tetrahydrofolate (THF). This study …
is a mitochondrial enzyme involved in the synthesis of tetrahydrofolate (THF). This study …