[PDF][PDF] Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters

MM Goodman, R Keil, TM Shoup… - Journal of Nuclear …, 1997 - Soc Nuclear Med
Results: Tissue distributionstudies in rats with [18F] FPCTshowed high striatal uptake
(0.70% dose/g at 60 min; 0.38% dose/g at 120 min) and good striatal-to-cerebellum ratios …

PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements

SS Zoghbi, HU Shetty, M Ichise, M Fujita… - Journal of Nuclear …, 2006 - Soc Nuclear Med
18F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane (18F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters

MM Goodman, CD Kilts, R Keil, B Shi… - Nuclear medicine and …, 2000 - Elsevier
Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane
(FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging …

Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I

T Sasaki, H Ito, Y Kimura, R Arakawa… - Journal of Nuclear …, 2012 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2 E-enyl)-2β-carbofluoroethoxy-3β-(4-methylphenyl) nortropane (18F-
FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine …

Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT

MR Davis, JR Votaw, JD Bremner… - Journal of Nuclear …, 2003 - Soc Nuclear Med
The aim of this study was to do an initial assessment of the usefulness of 2β-carbomethoxy-
3β-(4-chlorophenyl)-8-(2-18F-fluoroethyl) nortropane (18F-FECNT) PET scanning in …

[18F] β-CIT-FP is superior to [11C] β-CIT-FP for quantitation of the dopamine transporter

C Lundkvist, C Halldin, N Ginovart, CG Swahn… - Nuclear medicine and …, 1997 - Elsevier
β-CIT-FP [N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane] is a cocaine
analogue with high affinity for the dopamine transporter. Positron emission tomography …

Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [18F] FECT

SK Chitneni, L Garreau, B Cleynhens, N Evens… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION:[2′-[18F] Fluoroethyl (lR-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-
azabicyclo [3.2. 1]-octane-2-carboxylate]([18F] FECT) is a positron emission tomography …

Whole-body biodistribution and dosimetry of the dopamine transporter radioligand 18F-FE-PE2I in human subjects

H Lizana, L Johansson, J Axelsson… - Journal of Nuclear …, 2018 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl) nortropane
(18F-FE-PE2I) was recently developed and has shown adequate affinity and high selectivity …

Preparation of [18F]β‐CFT‐FP and [11C]β‐CFT‐FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)

EL Kämäräinen, T Kyllönen… - Journal of Labelled …, 2000 - Wiley Online Library
In this study the N‐fluoropropyl analogue of the cocaine congener β‐CFT (I), N‐(3‐
fluoropropyl)‐2β‐carbomethoxy‐3β‐(4‐fluorophenyl) nortropane (β‐CFT‐FP, III), was …

Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I

A Varrone, M Tóth, C Steiger, A Takano… - Journal of Nuclear …, 2011 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl) nortropane
(18F-FE-PE2I) is a novel radioligand for dopamine transporter (DAT) PET. As compared with …