Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma

AJ Day, G Williamson - British Journal of Nutrition, 2001 - cambridge.org
Quercetin, a polyphenol with potential health effects, is absorbed by humans and
measurement in plasma can be used as a biomarker for intake. However, the chemical …

Identification of quercetin 3-O-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin

JH Moon, T Tsushida, K Nakahara, J Terao - Free Radical Biology and …, 2001 - Elsevier
The potential beneficial effect of dietary quercetin (3, 3′, 4′, 5, 7-pentahydroxyflavone)
has attracted much attention in relation to the prevention of cardiovascular disease. It is …

[HTML][HTML] Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties

C Manach, C Morand, V Crespy, C Demigné, O Texier… - FEBS letters, 1998 - Elsevier
Quercetin is one of the most abundant flavonoids in the human diet. This study aimed to
determine the plasma concentrations of quercetin in 10 healthy volunteers after the …

[HTML][HTML] Bioavailability of quercetin in pigs is influenced by the dietary fat content

S Lesser, R Cermak, S Wolffram - The Journal of nutrition, 2004 - Elsevier
The flavonol quercetin is one of the most prevalent flavonoids found in edible plants. In this
study, the influence of dietary fat on oral bioavailability of quercetin was investigated …

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta

F Lodi, R Jimenez, L Moreno, PA Kroon, PW Needs… - Atherosclerosis, 2009 - Elsevier
Epidemiological studies have reported an inverse association between dietary flavonoid
intake and mortality for ischemic heart disease. Quercetin reduces blood pressure and …

Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials

A Sahebkar - Critical reviews in food science and nutrition, 2017 - Taylor & Francis
Background: In spite of promising experimental findings, randomized controlled trials (RCTs)
have yielded mixed results on the impact of quercetin supplementation on plasma lipid …

Absorption and disposition kinetics of the dietary antioxidant quercetin in man

PCH Hollman, MVD Gaag, MJB Mengelers… - Free Radical Biology …, 1996 - Elsevier
Quercetin is a dietary antioxidant that prevents oxidation of low-density lipoproteins in vitro
by scavenging of free oxygen radicals. Its intake was inversely associated with coronary …

Inhibitory effects of quercetin and its main methyl, sulfate, and glucuronic acid conjugates on cytochrome P450 enzymes, and on OATP, BCRP and MRP2 transporters

V Mohos, E Fliszár-Nyúl, O Ungvári, K Kuffa, PW Needs… - Nutrients, 2020 - mdpi.com
Quercetin is a flavonoid, its glycosides and aglycone are found in significant amounts in
several plants and dietary supplements. Because of the high presystemic biotransformation …

[HTML][HTML] Catechin is present as metabolites in human plasma after consumption of red wine

JL Donovan, JR Bell, S Kasim-Karakas, JB German… - The Journal of …, 1999 - Elsevier
Flavonoids are components of fruits, vegetables and wines. An abundance of flavonoids in
the diet is correlated with reduced heart disease mortality, suggesting that they act as …

The variable plasma quercetin response to 12-week quercetin supplementation in humans

F Jin, DC Nieman, RA Shanely, AM Knab… - European journal of …, 2010 - nature.com
Results: Quercetin supplementation over 12 weeks caused a significant increase in
overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q …