Cytokines are small, secreted proteins associated with the maintenance of immune
homeostasis but also implicated with the pathogenesis of several autoimmune and …

Chronic activation of immune responses, mediated by inflammatory mediators and involving
different effector cells of the innate and acquired immune system characterizes autoimmune …

JAKs are a family of intracellular tyrosine kinases consisting of four members, JAK1, JAK2,
JAK3, and TYK2. They are key components of the JAK-STAT pathway that transmit signals of …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Cytokine neutralization is successfully used for treatment of various autoimmune diseases
and chronic inflammatory conditions. The complex biology of the two well-characterized …

Systemic sclerosis and systemic lupus erythematosus represent two distinct autoimmune
diseases belonging to the group of connective tissue disorders. Despite the great progress …

Autoimmune and inflammatory diseases are common and diverse, and they can affect
nearly any organ system. Much of the pathogenesis of these diseases is related to …

Abstract The European Journal of Immunology was launched 50 years ago, coinciding with
the discovery of many cytokines and growth factors and the emergence of an entirely new …

Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …

Protein kinases mediate protein phosphorylation, which is a fundamental component of cell
signalling, with crucial roles in most signal transduction cascades: from controlling cell …