Chemical and structural diversity of siRNA molecules
B Nawrot, K Sipa - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
Short interfering RNAs (siRNAs) are 21-23 nt long double-stranded oligoribonucleotides
which in mammalian cells exhibit a potency for sequence-specific gene silencing via an …
which in mammalian cells exhibit a potency for sequence-specific gene silencing via an …
Chemically modified siRNA: tools and applications
Chemical modification provides solutions to many of the challenges facing siRNA
therapeutics. This review examines the various siRNA modifications available, including …
therapeutics. This review examines the various siRNA modifications available, including …
A review of the current status of siRNA nanomedicines in the treatment of cancer
P Resnier, T Montier, V Mathieu, JP Benoit, C Passirani - Biomaterials, 2013 - Elsevier
RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …
Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology
N Ebrahimi, MS Manavi, A Nazari, A Momayezi… - Environmental …, 2023 - Elsevier
RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …
[HTML][HTML] Nanoparticle-mediated systemic delivery of siRNA for treatment of cancers and viral infections
RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism,
where non-coding, double-stranded RNA molecules interfere with the expression of certain …
where non-coding, double-stranded RNA molecules interfere with the expression of certain …
Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
Advances in siRNA delivery in cancer therapy
A Singh, P Trivedi, NK Jain - Artificial cells, nanomedicine, and …, 2018 - Taylor & Francis
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to
seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the …
seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the …
Drug delivery of siRNA therapeutics: potentials and limits of nanosystems
D Reischl, A Zimmer - Nanomedicine: Nanotechnology, Biology and …, 2009 - Elsevier
Gene therapy is a promising tool for the treatment of human diseases that cannot be cured
by rational therapies. The major limitation for the use of small interfering RNA (siRNA), both …
by rational therapies. The major limitation for the use of small interfering RNA (siRNA), both …
[HTML][HTML] Therapeutic siRNA: state of the art
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …
against external invasion. It theoretically can silence any disease-related genes in a …
Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery
C Dohmen, D Edinger, T Fröhlich, L Schreiner… - ACS …, 2012 - ACS Publications
Although our understanding of RNAi and our knowledge on designing and synthesizing
active and safe siRNAs significantly increased during the past decade, targeted delivery …
active and safe siRNAs significantly increased during the past decade, targeted delivery …