The pharmacokinetics of tazobactam (500 mg) administered intravenously alone were
compared with the pharmacokinetics of tazobactam coadministered with piperacillin (4 g) …

The pharmacokinetic properties of piperacillin/tazobactam are summarized. The data on
piperacillin show that the behaviour of this well established agent is the same when given in …

The pharmacokinetics of tazobactam and piperacillin in plasma and different tissues after a
30-min intravenous infusion of 4 g of piperacillin and 0.5 g of tazobactam were investigated …

A 1: 4 by weight of combination of tazobactam, a new β-lactamase inhibitor, and piperacillin,
is now under development in Japan. After bolus iv administration of the combination to …

Study Objective. To compare the pharmacokinetic and pharmacodynamic profiles of two
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …

Tazobactam is an irreversible inhibitor of many β‐lactamases. In combination with
piperacillin, tazobactam exhibits synergy against many β‐lactamase? producing bacteria …

Piperacillin/tazobactam is a new combination of a broad-spectrum penicillin and a beta-
lactamase inhibitor. In studies in healthy volunteers, the pharmacokinetics of piperacillin …

ABSTRACT A population pharmacokinetic (PK) analysis was conducted to determine if
piperacillin and tazobactam exhibited linear or nonlinear PKs and if incremental changes in …

The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …

The investigation of tissue penetration and distribution of antibiotics is of great importance,
since infections occur mostly in the tissues. The aim of this study was to investigate the …