Pharmacokinetics has evolved from its origin into a complex discipline with numerous
subspecialties and applications in patient management, drug development, and regulatory …

Highlights•Model-informed drug discovery and development (MID3) is poised to facilitate a
major evolution in the way drugs R&D is conducted.•Employing computational models aids …

A 2-day workshop on “Physiologically Based Pharmacokinetics (PBPK) in Drug
Development and Regulatory Science” came to a successful conclusion on May 30, 2002, in …

The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

Modeling is an important tool in drug development; population modeling is a complex
process requiring robust underlying procedures for ensuring clean data, appropriate …

We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations The first book
dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK) …

Population pharmacokinetic models are used to describe the time course of drug exposure
in patients and to investigate sources of variability in patient exposure. They can be used to …

Discontinuation of drug development projects due to lack of efficacy or adverse events is
one of the main cost drivers in pharmaceutical research and development (R&D) …

With the rapidly changing health care and research environments, it has become essential
that the drug development process achieve greater efficiency, cost-effectiveness and …