Introduction: Glaucoma is a prevalent ocular disease with characteristic optic disc and visual
field changes. Globally, it is the second most common cause of visual disability, and the …

Elevated eye pressure is the main risk factor for glaucoma, and intraocular pressure rises
when the balance between aqueous humor formation and outflow resistance is …

Elevated eye pressure is the main risk factor for glaucoma; intraocular pressure rises when
the ratio between aqueous humor formation (inflow) and its outflow is unbalanced. Currently …

Glaucoma causes irreversible vision loss, with elevated intraocular pressure (IOP) being the
only known modifiable risk factor. There are a variety of medical and interventional options …

Glaucoma is a group of progressive optic neuropathies in which the axons in the optic nerve
are injured, retinal ganglion cell numbers are reduced and vision is gradually and …

Primary open-angle glaucoma (OAG) affects approximately 45 million people worldwide and
more than 2.5 million people aged 40 years or older in the United States. Pharmacologic …

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Introduction: Glaucoma is the second leading cause of blindness in the world and current
pharmacotherapies for glaucoma have remained relatively unchanged (with the exception of …

Introduction: Glaucoma is a disease of the eye in which the optic nerve and retinal ganglion
cells (RGCs) are injured, leading to the loss of the peripheral visual field and eventually to …

While many pharmacological treatments exist to lower elevated intraocular pressure (IOP),
many patients require more than one medication, and thus there remains a need for novel …