The first signal is antigen specific; it is delivered via the antigen-specific T-cell surface
receptor (TCR) when antigen is properly presented to the T cell in the context of major …

Abstract CD40 ligand, a 33‐kDa cell membrane molecule, a member of the tumor necrosis
factor superfamily, is an important costimulatory molecule during immune response. Here …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

It is clear by now that cell-to-cell interactions involving a variety of signals are required for
effective immune response. The data reviewed here suggest that CD40-CD40L interactions …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

A successful immune response requires the coordinated interaction of multiple cell types.
The interactioti between T-helper cells (Th) and antigen-presenting cells (APC) such as B …

CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …

Background: T cells and B cells communicate by direct cell–cell interaction that is crucial to
the functioning of the immune system. It is well established that the interaction between B …

Generation of an effective immune response against foreign antigens requires two distinct
molecular signals: a primary signal provided by the binding of antigen-specific T-cell …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor receptor family. It
was first identified and functionally characterized on B lymphocytes; however, in recent …