ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Abstract ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes
SWI/SNF chromatin remodelers play critical roles in development and cancer. The causal
links between SWI/SNF complex disassembly and carcinogenesis are obscured by …
links between SWI/SNF complex disassembly and carcinogenesis are obscured by …
[HTML][HTML] ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy
R Okamura, S Kato, S Lee, RE Jimenez… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Several cancer types harbor alterations in the gene encoding AT-Rich
Interactive Domain-containing protein 1A (ARID1A), but there are no approved therapies to …
Interactive Domain-containing protein 1A (ARID1A), but there are no approved therapies to …
ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors
Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
[HTML][HTML] Pan-cancer analysis of ARID1A alterations as biomarkers for immunotherapy outcomes
T Jiang, X Chen, C Su, S Ren, C Zhou - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
ARID1A alterations would compromise mismatch repair pathway and increase the number
of tumor-infiltrating lymphocytes and PD-L1 expression in some cancers, which would …
of tumor-infiltrating lymphocytes and PD-L1 expression in some cancers, which would …
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy
Whether mutations in cancer driver genes directly affect cancer immune phenotype and T
cell immunity remains a standing question. ARID1A is a core member of the polymorphic …
cell immunity remains a standing question. ARID1A is a core member of the polymorphic …
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most
frequently mutated genes in human cancer. We sought to develop rational combination …
frequently mutated genes in human cancer. We sought to develop rational combination …
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …
either open or close configuration at specific chromatin locations by orchestrating and …
ARID1A mutations in cancer development: mechanism and therapy
X Zhang, Y Zhang, J Zhao, Y Wu, N Zhang… - …, 2023 - academic.oup.com
Abstract AT-Rich Interaction Domain 1A (ARID1A) is an important SWItch/Sucrose Non-
Fermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a …
Fermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a …