Nature has hardly evolved a biochemistry of fluorine although there is a low-level
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …

Fluorinated compounds are finding increasing uses in several applications. They are
employed in almost all areas of modern society. These compounds are all produced by …

Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Organofluorine compounds are rare in Nature, with only a handful known to be produced by
some species of plant and two microorganisms. Consequently, the mechanism of enzymatic …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

It is now more than 50 years since the first fluorinated natural product was identified. In that
time only about a dozen fluorinated natural products have been isolated, the last one over a …

The incorporation of fluorine has been shown to improve the biophysical and bioactive
properties of several organic compounds. However, sustainable strategies of fluorination are …

Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

Organofluorine compounds play an important role in medicinal chemistry, where they are
responsible for up to 15% of the pharmaceutical products on the market. While natural …