EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer

M Bartolotti, E Franceschi… - Expert review of anticancer …, 2012 - Taylor & Francis
The incidence of brain metastasis (BM) is high in patients with non-small-cell lung cancer.
Available standard therapeutic options, such as whole-brain radiation therapy and systemic …

Role of EGFR inhibitors in the treatment of central nervous system metastases from non-small cell lung cancer

GL Ceresoli - Current Cancer Drug Targets, 2012 - ingentaconnect.com
Brain metastases (BM) are a common occurrence in patients with non-small cell lung cancer
(NSCLC). Standard therapy options include whole brain radiotherapy and, in selected …

The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer

H Bai, B Han - OncoTargets and therapy, 2017 - Taylor & Francis
Brain metastases are usual in non-small-cell lung cancer (NSCLC) with poor prognosis and
few available therapeutic options. This retrospective study aims to evaluate the efficacy of …

Paradigm shift of therapeutic management of brain metastases in EGFR-mutant non-small cell lung cancer in the era of targeted therapy

A Sekine, H Satoh - Medical Oncology, 2017 - Springer
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)
mutations commonly present brain metastases (BM) at the time of NSCLC diagnosis or …

[HTML][HTML] Cranial irradiation in patients with EGFR-mutant non-small cell lung cancer brain metastases

TJ Yang, AJ Wu - Translational Lung Cancer Research, 2016 - ncbi.nlm.nih.gov
The most effective treatment approach for brain metastases in patients with non-small cell
lung cancer (NSCLC) and activating epidermal growth factor receptor (EGFR) mutations is a …

Gefitinib and erlotinib for non-small cell lung cancer patients who fail to respond to radiotherapy for brain metastases

Z Song, Y Zhang - Journal of Clinical Neuroscience, 2014 - Elsevier
Survival and treatment options are limited for patients with brain metastases arising from non-
small cell lung cancer (NSCLC). We evaluated erlotinib and gefitinib as salvage treatments …

EGFR-TKI therapy for patients with brain metastases from non-small-cell lung cancer: a pooled analysis of published data

Y Fan, X Xu, C Xie - OncoTargets and therapy, 2014 - Taylor & Francis
Introduction Brain metastases are one of the leading causes of death from non-small-cell
lung cancer (NSCLC). The use of epidermal growth factor receptor (EGFR) tyrosine kinase …

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in the Treatment of Epidermal Growth Factor ReceptorMutant Non–Small Cell Lung Cancer Metastatic …

M Jamal-Hanjani, J Spicer - Clinical Cancer Research, 2012 - AACR
Brain metastases are a common and devastating consequence of disease progression in
patients with non–small cell lung cancer (NSCLC). The epidermal growth factor receptor …

[HTML][HTML] Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of central nervous system metastases from non-small cell lung cancer: the present …

C Proto, M Imbimbo, R Gallucci, A Brissa… - … lung cancer research, 2016 - ncbi.nlm.nih.gov
Lung cancer is one of the major causes of cancer related mortality worldwide. Brain
metastases (BM) complicate clinical evolution of non-small cell lung cancer (NSCLC) in …

Epidermal growth factor receptor tyrosine kinase inhibitors for central nervous system metastases from non‐small cell lung cancer

MS Ahluwalia, K Becker, BP Levy - The Oncologist, 2018 - academic.oup.com
Central nervous system (CNS) metastases are a common complication in patients with
epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer (NSCLC) …