Background: Septic shock represents the major cause of infection-associated mortality in the
intensive care unit. The possibility that combination antibiotic therapy of bacterial septic …

Objective: To assess whether a potential benefit with combination antibiotic therapy is
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …

There has been little improvement in septic shock mortality in the past 70 years, despite ever
more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have …

The optimal approach for empirical antibiotic therapy in patients with severe sepsis and
septic shock remains controversial. A retrospective cohort study was conducted in the …

This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The
article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for …

Study objective Debate exists about the mortality benefit of administering antibiotics within
either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of …

Objectives: We evaluated the respective influence of the causative pathogen and infection
site on hospital mortality from severe sepsis related to community-, hospital-, and intensive …

Objective: To assess whether combination antibiotic therapy improves outcome of severe
community-acquired pneumonia in the subset of patients with shock. Design: Secondary …

Objective Our goal was to determine the impact of the initiation of inappropriate antimicrobial
therapy on survival to hospital discharge of patients with septic shock. Methods The …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …