[HTML][HTML] Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture

A Crane, RM Shanahan, JS Hudson… - Journal of Clinical …, 2024 - mdpi.com
Management of intracranial aneurysms (IAs) is determined by patient age, risk of rupture,
and comorbid conditions. While endovascular and microsurgical interventions offer solutions …

Role of Inflammatory Mediators in Intracranial Aneurysms: A Review

C Chen, F Tang, M Zhu, C Wang, H Zhou… - Clinical Neurology and …, 2024 - Elsevier
The formation, growth, and rupture of intracranial aneurysms (IAs) involve hemodynamics,
blood pressure, external stimuli, and a series of hormonal changes. In addition, inflammatory …

Risk factor management matters more than pharmaceutical cyclooxygenase‐2 inhibition in the prevention of de novo intracranial aneurysms

S Räisänen, J Huttunen, TJ Huuskonen… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Pathophysiological studies of saccular intracranial aneurysm (sIA)
disease have shown that inflammation plays a crucial role in sIA development …

[HTML][HTML] Candidate drugs for preventive treatment of unruptured intracranial aneurysms: A cross-sectional study

K Shimizu, H Imamura, S Tani, H Adachi, C Sakai… - PloS one, 2021 - journals.plos.org
Background and purpose Establishment of drug therapy to prevent rupture of unruptured
intracranial aneurysms (IAs) is needed. Previous human and animal studies have gradually …

[HTML][HTML] Aspirin treatment for unruptured intracranial aneurysms: Focusing on its anti-inflammatory role

Y Feng, H Zhang, S Dai, X Li - Heliyon, 2024 - cell.com
Intracranial aneurysms (IAs), as a common cerebrovascular disease, claims a worldwide
morbidity rate of 3.2%. Inflammation, pivotal in the pathogenesis of IAs, influences their …

Roles of inflammation in the natural history of intracranial saccular aneurysms

J Wang, L Wei, H Lu, Y Zhu - Journal of the Neurological Sciences, 2021 - Elsevier
Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and
results in high rates of mortality and morbidity. Factors contributing to IA generation, growth …

“Sit back, observe, and wait.” Or is there a pharmacologic preventive treatment for cerebral aneurysms?

MM Valença - Neurosurgical review, 2013 - Springer
Intracranial aneurysms (IA) are a relatively frequent vascular abnormality. The prevailing
opinion is that cerebral aneurysmal disease is related to hemodynamic and genetic factors …

[HTML][HTML] Potential therapeutic strategies for intracranial aneurysms targeting aneurysm pathogenesis

Z Liu, K Ajimu, N Yalikun, Y Zheng, F Xu - Frontiers in Neuroscience, 2019 - frontiersin.org
Subarachnoid hemorrhage resulting from intracranial aneurysms (IAs) is associated with
high rates of morbidity and mortality. Although trigger mechanisms in the pathogenesis of …

[HTML][HTML] Statins as a candidate of drugs for intracranial aneurysm treatment

K Tsuji, T Aoki, M Fukuda, K Nozaki - Health, 2014 - scirp.org
The treatment for intracranial aneurysm (IA) is socially important because of poor outcome
posed by subarachnoid hemorrhage after rupture. Further, the incidence of IAs in general …

Nonsteroidal anti-inflammatory drugs: a potential pharmacological treatment for intracranial aneurysm

CL Fisher, SL Demel - Cerebrovascular diseases extra, 2019 - karger.com
Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of
intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated …