In recent years, a number of mammalian zinc transporters have been identified, and
candidate genes are rapidly growing. These transporters are classified into two families: ZIP …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc is an essential metal for all eukaryotes, and cells have evolved a complex system of
proteins to maintain the precise balance of zinc uptake, intracellular storage, and efflux. In …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

The last ten years have witnessed major advances in our understanding of zinc transporters
and their regulation in eukaryotic organisms. Two families of transporters, the ZIP (Zrt-, I rt …

Zinc is required for the regulation of proliferation, metabolism, and cell signaling. It is an
intracellular second messenger, and the cellular level of ionic, mobile zinc is strictly …

Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

The mouse mZip1 and mZip3 zinc transporters have been implicated in zinc acquisition by
the cells of many tissues. This hypothesis raised the question of whether activity of these …