Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis
S Hua, M Ma, X Fei, Y Zhang, F Gong… - International …, 2019 - Elsevier
Gasdermin D (GSDMD), a genetic substrate for inflammatory caspases, plays a central role
in pyroptosis of macrophages and release of interleukin‑1β (IL-1β), but was mainly referred …
in pyroptosis of macrophages and release of interleukin‑1β (IL-1β), but was mainly referred …
Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats
M Ogiku, H Kono, M Hara, M Tsuchiya, H Fujii - Journal of Pharmacology …, 2011 - ASPET
High-mobility group box 1 (HMGB1) acts as an early mediator of inflammation and organ
damage in hepatic ischemia-reperfusion (I/R) injury. Glycyrrhizin is a natural anti …
damage in hepatic ischemia-reperfusion (I/R) injury. Glycyrrhizin is a natural anti …
Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1
P Fang, J Liang, X Jiang, X Fang, M Wu… - Frontiers in …, 2020 - frontiersin.org
High mobility group box-1 (HMGB1) plays an important role in various liver injuries. In the
case of acute liver injury, it leads to aseptic inflammation and other reactions, and also …
case of acute liver injury, it leads to aseptic inflammation and other reactions, and also …
[HTML][HTML] Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway
GY Gwak, TG Moon, DH Lee… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To examine how high-mobility group box 1 (HMGB1) regulates hepatocyte apoptosis
and, furthermore, to determine whether glycyrrhizin (GL), a known HMGB1 inhibitor …
and, furthermore, to determine whether glycyrrhizin (GL), a known HMGB1 inhibitor …
Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury
Pyroptosis, a proinflammatory form of programmed cell death, plays important roles in the
pathogenesis of many diseases. Inflammasome activation, which has been shown in hepatic …
pathogenesis of many diseases. Inflammasome activation, which has been shown in hepatic …
Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats
G Gong, L Xiang, L Yuan, L Hu, W Wu, L Cai, L Yin… - PloS one, 2014 - journals.plos.org
Aim Gl y cyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-
induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In the …
induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In the …
LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and caspase-11/GSDMD signaling
W Li, M Deng, PA Loughran, M Yang, M Lin… - Frontiers in …, 2020 - frontiersin.org
High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …
Glycyrrhizin protects rats from sepsis by blocking HMGB1 signaling
F Zhao, Y Fang, S Deng, X Li, Y Zhou… - BioMed research …, 2017 - Wiley Online Library
Background. HMGB1 acts as an important inflammatory mediator and is a potential
therapeutic target for sepsis. Glycyrrhizin (GL), a natural triterpene glycoside derived from …
therapeutic target for sepsis. Glycyrrhizin (GL), a natural triterpene glycoside derived from …
HMGB1-induced hepatocyte pyroptosis expanding inflammatory responses contributes to the pathogenesis of acute-on-chronic liver failure (ACLF)
W Hou, X Wei, J Liang, P Fang, C Ma… - Journal of …, 2021 - Taylor & Francis
Background Acute-on-chronic liver failure (ACLF) is a critical disease with a high fatality rate.
Immune dysfunction and inflammatory responses are key risk factors in ACLF. Pyroptosis is …
Immune dysfunction and inflammatory responses are key risk factors in ACLF. Pyroptosis is …
Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice
W Lee, SK Ku, JS Bae - Toxicology and Applied Pharmacology, 2017 - Elsevier
High mobility group box 1 (HMGB1) is considered a late mediator of sepsis and the
inhibition of HMGB1-mediated severe inflammatory responses and restoration of endothelial …
inhibition of HMGB1-mediated severe inflammatory responses and restoration of endothelial …