Effect of proton and gamma irradiation on human lung carcinoma cells: Gene expression, cell cycle, cell death, epithelial–mesenchymal transition and cancer-stem …

H Narang, A Kumar, N Bhat, BN Pandey… - … Molecular Mechanisms of …, 2015 - Elsevier
Proton beam therapy is a cutting edge modality over conventional gamma radiotherapy
because of its physical dose deposition advantage. However, not much is known about its …

Low energy proton beam induces efficient cell killing in A549 lung adenocarcinoma cells

S Ghosh, NN Bhat, S Santra, RG Thomas… - Cancer …, 2010 - Taylor & Francis
The aim of the current study was to determine the signaling differences between γ-and
proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton …

Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions

OD Keta, DV Todorović, TM Bulat… - Experimental …, 2017 - journals.sagepub.com
The aim of this study was to investigate effects of irradiations with the therapeutic proton and
carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and …

Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth

S Girdhani, C Lamont, P Hahnfeldt… - Radiation …, 2012 - meridian.allenpress.com
The energy deposition characteristics of proton radiation have attracted considerable
attention in light of its implications for carcinogenesis risk in space travel, as well for …

Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination

AC Wéra, AC Heuskin, H Riquier… - Radiation …, 2013 - meridian.allenpress.com
Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used
for cancer treatment. More recently, studies on the use of proton therapy in the treatment of …

Suppressive effects of a proton beam on tumor growth and lung metastasis through the inhibition of metastatic gene expression in 4T1 orthotopic breast cancer model

YS Kwon, KS Lee, SY Chun… - … Journal of Oncology, 2016 - spandidos-publications.com
A proton beam is a next generation tool to treat intractable cancer. Although the therapeutic
effects of a proton beam are well known, the effect on tumor metastasis is not fully described …

Proton radiation-induced cancer progression

K Luitel, R Bozeman, A Kaisani, SB Kim… - Life sciences in space …, 2018 - Elsevier
There are considerable health risks related to ionizing and proton radiation exposure. While
there is a long history of health risks associated with ionizing (photon) radiation exposure …

Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases

KB Lee, JS Lee, JW Park, TL Huh… - Experimental & molecular …, 2008 - nature.com
Proton beam is useful to target tumor tissue sparing normal cells by allowing precise dose
only into tumor cells. However, the cellular and molecular mechanisms by which proton …

Proton irradiation induced reactive oxygen species promote morphological and functional changes in HepG2 cells

M Răileanu, M Straticiuc, DA Iancu, RF Andrei… - Journal of Structural …, 2022 - Elsevier
The increased use of proton therapy has led to the need of better understanding the cellular
mechanisms involved. The aim of this study was to investigate the effects induced by the …

Proton therapy targets cancer stem cells in treatment-resistant non-small cell lung cancer

JY Chang, X Zhang, O Vassiliev, M Gillin… - International Journal of …, 2010 - redjournal.org
Results At the same dose (RBE), protons killed significantly more than did photons (p< 0.05),
but this effect was not seen in NHBE cells. Protons induced significant increases in …