The equal potency and efficacy of the agonists, ATP and UTP, pharmacologically distinguish
the P2Y 2 receptor from other nucleotide receptors. Investigation of the desensitization of the …

The action of extracellular nucleotides, specifically the ability of adenine nucleotides to
induce coronary vasodilation and bradycardia, was first described more than 70 years ago …

Adenosine triphosphate (ATP), a co-transmitter in sympathetic nerves and released from
platelets, has recently been shown to stimulate growth of vascular smooth muscle cells. It …

The P2Y family of receptors are G protein‐coupled receptors for ATP, ADP, UTP and UDP.
Recently several members of this family have been cloned, including the P2Y4, which is …

1 We have examined the effects of various purine and pyrimidine nucleotides upon cells
cultured from guinea‐pig cardiac endothelium (CEC), and find the P2Y‐agonist 2 …

Effects of UTP have been described in many tissues, but it is not clear whether these are due
to purinoceptors. Specific receptors for UTP,'pyrimidinoceptors', and 'nucleotide receptors' …

The human P2Y1 purinoceptor has been expressed in Jurkat cells and the effects of HPLC
purified nucleotides on calcium movements were measured. The most potent agonist was 2 …

We have examined a series of adenine nucleotides and UTP for their ability to cause
relaxation of precontracted bovine aortic collateral artery nngs. The overall rank order of …

Although P2 receptors mediate a myriad of physiological effects of extracellular adenine
nucleotides, study of this broad class of receptors has been compromised by a lack of P2 …

Purinoceptor responses were analyzed in B10 cells, a clonal population of rat brain capillary
endothelial cells. 2. B10 cells lack P2U receptors as evidenced by the lack of UTP …