Cyclooxygenase-2 and its role in colorectal cancer development
D Wendum, J Masliah, G Trugnan, JF Fléjou - Virchows Archiv, 2004 - Springer
Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …
involved in colorectal tumor development. This review deals with particular questions raised …
Role of cyclooxygenase-2 in colorectal cancer
FA Sinicrope, S Gill - Cancer and Metastasis Reviews, 2004 - Springer
Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
Cyclooxygenases and colon cancer
N Kawai, M Tsujii, S Tsuji - Prostaglandins & Other Lipid Mediators, 2002 - Elsevier
There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …
Cyclo-oxygenase 2 inhibition in colorectal cancer therapy
RD Church, JW Fleshman… - Journal of British …, 2003 - academic.oup.com
Background Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …
Role of cyclooxygenase-2 in the angiogenesis of colorectal cancer
M Rao, W Yang, AM Seifalian, MC Winslet - International Journal of …, 2004 - Springer
Background Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of
prostaglandins. It exists in two isoforms: COX-1 which is constitutively expressed and COX-2 …
prostaglandins. It exists in two isoforms: COX-1 which is constitutively expressed and COX-2 …
[HTML][HTML] Role of cyclooxygenase-2 in colorectal cancer
Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …
cyclooxygenase–a target for colon cancer prevention
RN Dubois - Alimentary Pharmacology & Therapeutics, 2000 - Wiley Online Library
Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …
Translational studies on Cox‐2 inhibitors in the prevention and treatment of colon cancer
RA Gupta, RN DuBOIS - Annals of the New York Academy of …, 2000 - Wiley Online Library
Inhibitors of the inducible cyclooxygenase (COX‐2) have emerged as a promising new class
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …
Cyclooxygenase-2 and carcinogenesis.
SM Prescott, FA Fitzpatrick - Biochimica et biophysica acta, 2000 - europepmc.org
Numerous investigations have shown that COX-2 is a participant in the pathway of colon
carcinogenesis, especially when mutation of the APC tumor suppressor is the initiating …
carcinogenesis, especially when mutation of the APC tumor suppressor is the initiating …
Human colorectal adenomas demonstrate a size‐dependent increase in epithelial cyclooxygenase‐2 expression
DJE Elder, JA Baker, NA Banu… - The Journal of …, 2002 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs are chemopreventive for colorectal cancer. This
effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2) …
effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2) …