Low-dose albumin-coated gold nanorods induce intercellular gaps on vascular endothelium by causing the contraction of cytoskeletal actin

Z Li, J Liu, K Ballard, C Liang, C Wang - Journal of Colloid and Interface …, 2023 - Elsevier
Cytotoxicity of nanoparticles, typically evaluated by biochemical-based assays, often
overlook the cellular biophysical properties such as cell morphology and cytoskeletal actin …

Toxicity and cellular uptake of gold nanorods in vascular endothelium and smooth muscles of isolated rat blood vessel: importance of surface modification

AM Alkilany, A Shatanawi, T Kurtz, RB Caldwell… - Small, 2012 - Wiley Online Library
Gold nanorods (GNRs) have promising applications in drug delivery and cancer treatment
and are generally administered via direct injection into the circulation. Thus it is necessary to …

Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells

Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …

Endothelial barrier dysfunction induced by nanoparticle exposure through actin remodeling via caveolae/raft-regulated calcium signalling

Y Liu, E Yoo, C Han, GJ Mahler, AL Doiron - NanoImpact, 2018 - Elsevier
The rapid development of modern nanotechnology has resulted in nanomaterial being use
in nearly all applications of life, raising the potential risk of nanomaterial exposure alongside …

Correlating ligand density with cellular uptake of gold nanorods revealed by X-ray reflectivity

P Quan, W Bu, B Lin, X Jiang… - Journal of Nanoscience …, 2019 - ingentaconnect.com
Ligands can endow unique physicochemical properties of nanomaterials and also mediate
biological effects of nanomaterials. It is unclear whether the ligand density affects cytotoxicity …

In vitro effects of hollow gold nanoshells on human aortic endothelial cells

C Gu, H Wu, G Ge, X Li, Z Guo, Z Bian, J Xu… - Nanoscale Research …, 2016 - Springer
Gold nanoparticles are emerging as promising biomedical tools due to their unique
nanoscale characteristics. Our purpose was to synthesize a hollow-shaped gold …

Cytotoxicity and cellular responses of gold nanorods to smooth muscle cells dependent on surface chemistry coupled action

Q Sun, X Shi, J Feng, Q Zhang, Z Ao, Y Ji, X Wu, D Liu… - Small, 2018 - Wiley Online Library
Gold nanorods (AuNRs), with their unique physicochemical properties, are recognized as
promising materials for biomedical applications. Chemical modification of their surfaces is …

Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …

T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …

Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …

TH Lai, CH Chung, BH Chen, CF Hung… - Journal of …, 2016 - ingentaconnect.com
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …

Dynamic protein corona of gold nanoparticles with an evolving morphology

A Nandakumar, W Wei, G Siddiqui… - … applied materials & …, 2021 - ACS Publications
Much has been learned about the protein coronae and their biological implications within
the context of nanomedicine and nanotoxicology. However, no data is available about the …