We have previously demonstrated the chronic hypotensive effects of the AT 1 antagonist
losartan in normotensive, salt-replete rats. We hypothesized that the chronic effects of …

To clarify the role of endogenous angiotensin II (Angli) in the hypertension of spontaneously
hypertensive rats (SHR), we examined the chronic effects of central and systemic …

Objective Numerous studies have shown that angiotensin II enhances sympathetic nervous
transmission. The objective of the present study was to quantify the inhibitory effect of the …

The effects of in vivo treatment with the nonpeptide subtype 1 angiotensin II receptor
antagonist, losartan, on blood pressure and vascular reactivity in normotensi male Sprague …

1. The blood pressure, heart rate, hormonal and pressor responses to constant rate infusion
of various doses of the angiotensin (type 1) receptor antagonist Losartan (DuP 753/MK 954) …

Nonselective inhibition of endogenous angiotensin II (All) by AI-converting enzyme inhibitors
(ACEI) results in sympathoinhibitory effects. We wished to examine the influence of selective …

Systolic hypertension is a major risk factor for cardiovascular disease. The determinants of
systolic blood pressure are peripheral resistance and arterial compliance. Arterial …

Experiments were carried out in conscious dexamethasone-treated cynomolgus monkeys in
an attempt to determine if losartan (DuP753) inhibited endogenous as well as exogenous …

Objective In a conscious unrestrained rat model, it takes approximately 1 week for
angiotensin II to increase blood pressure to maximum levels. We investigated the time …

We have previously demonstrated the chronic hypotensive effects of the AT 1 antagonist,
losartan, in normotensive, salt-replete rats. One explanation for this response is a reduction …